181341

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3437050..3437670 Replicon chromosome
Accession NZ_CP064666
Organism Salmonella sp. SJTUF14154

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag IVP16_RS16745 Protein ID WP_001280991.1
Coordinates 3437452..3437670 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag IVP16_RS16740 Protein ID WP_000344807.1
Coordinates 3437050..3437424 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP16_RS16730 3432189..3433382 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IVP16_RS16735 3433405..3436554 + 3150 WP_051129102.1 efflux RND transporter permease AcrB -
IVP16_RS16740 3437050..3437424 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
IVP16_RS16745 3437452..3437670 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
IVP16_RS16750 3437849..3438400 + 552 WP_001278793.1 maltose O-acetyltransferase -
IVP16_RS16755 3438518..3438988 + 471 WP_000136181.1 membrane protein -
IVP16_RS16760 3439044..3439184 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
IVP16_RS16765 3439190..3439450 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
IVP16_RS16770 3439675..3441225 + 1551 WP_023210786.1 EAL domain-containing protein -
IVP16_RS16780 3441456..3441845 + 390 WP_000961285.1 MGMT family protein -
IVP16_RS16785 3441878..3442447 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T181341 WP_001280991.1 NZ_CP064666:3437452-3437670 [Salmonella sp. SJTUF14154]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T181341 NZ_CP085821:345346-345633 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT181341 WP_000344807.1 NZ_CP064666:3437050-3437424 [Salmonella sp. SJTUF14154]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT181341 NZ_CP085821:345620-345922 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References