Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2458140..2458662 Replicon chromosome
Accession NZ_CP064666
Organism Salmonella sp. SJTUF14154

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag IVP16_RS11915 Protein ID WP_000221343.1
Coordinates 2458378..2458662 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag IVP16_RS11910 Protein ID WP_000885424.1
Coordinates 2458140..2458388 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP16_RS11890 2453782..2455248 + 1467 WP_023893409.1 hypothetical protein -
IVP16_RS11895 2455865..2456113 + 249 Protein_2328 helix-turn-helix domain-containing protein -
IVP16_RS11900 2456224..2457132 - 909 WP_077910000.1 hypothetical protein -
IVP16_RS11905 2457283..2457615 - 333 WP_023227504.1 DUF1493 family protein -
IVP16_RS11910 2458140..2458388 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IVP16_RS11915 2458378..2458662 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IVP16_RS11920 2458710..2458910 + 201 Protein_2333 RidA family protein -
IVP16_RS11925 2458962..2460041 - 1080 WP_023227502.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
IVP16_RS11930 2460234..2460722 - 489 WP_023227501.1 MarR family winged helix-turn-helix transcriptional regulator -
IVP16_RS11935 2460767..2462275 + 1509 WP_023227500.1 FAD-dependent oxidoreductase -
IVP16_RS11940 2462265..2463506 + 1242 WP_023227499.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2455297..2465132 9835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T181340 WP_000221343.1 NZ_CP064666:2458378-2458662 [Salmonella sp. SJTUF14154]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T181340 NZ_CP085821:301332-301640 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT181340 WP_000885424.1 NZ_CP064666:2458140-2458388 [Salmonella sp. SJTUF14154]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT181340 NZ_CP085821:301090-301329 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References