Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 852959..853584 Replicon chromosome
Accession NZ_CP064666
Organism Salmonella sp. SJTUF14154

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IVP16_RS04175 Protein ID WP_000911337.1
Coordinates 853186..853584 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag IVP16_RS04170 Protein ID WP_000557545.1
Coordinates 852959..853186 (+) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP16_RS04140 848004..849521 + 1518 WP_000003339.1 lysine--tRNA ligase -
IVP16_RS04145 849597..850142 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
IVP16_RS04150 850407..851165 + 759 WP_000244318.1 peptidoglycan DD-metalloendopeptidase family protein -
IVP16_RS04160 851450..852256 - 807 WP_010989071.1 DUF1460 domain-containing protein -
IVP16_RS04165 852531..852791 - 261 WP_023227725.1 hypothetical protein -
IVP16_RS04170 852959..853186 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
IVP16_RS04175 853186..853584 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
IVP16_RS04180 854388..854924 + 537 WP_023227726.1 STM3031 family outer membrane protein -
IVP16_RS04185 854971..855603 + 633 WP_023227727.1 YfdX family protein -
IVP16_RS04190 856322..856909 + 588 WP_023227728.1 fimbrial protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 851450..862777 11327


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-123)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T181330 WP_000911337.1 NZ_CP064666:853186-853584 [Salmonella sp. SJTUF14154]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T181330 NZ_CP085820:1899333-1899644 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT181330 WP_000557545.1 NZ_CP064666:852959-853186 [Salmonella sp. SJTUF14154]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT181330 NZ_CP085820:1899645-1899935 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References