Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4618655..4619271 Replicon chromosome
Accession NZ_CP064663
Organism Salmonella sp. SJTUF14170

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IVP17_RS22325 Protein ID WP_064163215.1
Coordinates 4618655..4619029 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E9YHE9
Locus tag IVP17_RS22330 Protein ID WP_001523745.1
Coordinates 4619029..4619271 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP17_RS22310 4616157..4617059 + 903 WP_051129234.1 formate dehydrogenase subunit beta -
IVP17_RS22315 4617056..4617691 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
IVP17_RS22320 4617688..4618617 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
IVP17_RS22325 4618655..4619029 - 375 WP_064163215.1 type II toxin-antitoxin system VapC family toxin Toxin
IVP17_RS22330 4619029..4619271 - 243 WP_001523745.1 ribbon-helix-helix domain-containing protein Antitoxin
IVP17_RS22335 4619476..4620405 + 930 WP_001162861.1 alpha/beta hydrolase -
IVP17_RS22340 4620491..4620802 + 312 WP_000558165.1 type II toxin-antitoxin system HigB family toxin -
IVP17_RS22345 4620799..4621245 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
IVP17_RS22350 4621260..4622201 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
IVP17_RS22355 4622246..4622683 - 438 WP_000560969.1 D-tyrosyl-tRNA(Tyr) deacylase -
IVP17_RS22360 4622680..4623552 - 873 WP_000921423.1 virulence factor BrkB family protein -
IVP17_RS22365 4623546..4624145 - 600 WP_023227076.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13942.20 Da        Isoelectric Point: 7.3567

>T181327 WP_064163215.1 NZ_CP064663:c4619029-4618655 [Salmonella sp. SJTUF14170]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHF

Download         Length: 375 bp

>T181327 NZ_CP085820:c1337790-1337515 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.77 Da        Isoelectric Point: 4.4463

>AT181327 WP_001523745.1 NZ_CP064663:c4619271-4619029 [Salmonella sp. SJTUF14170]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp

>AT181327 NZ_CP085820:c1338053-1337793 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References