Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3425630..3426250 Replicon chromosome
Accession NZ_CP064663
Organism Salmonella sp. SJTUF14170

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag IVP17_RS16700 Protein ID WP_001280991.1
Coordinates 3426032..3426250 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag IVP17_RS16695 Protein ID WP_000344807.1
Coordinates 3425630..3426004 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP17_RS16685 3420769..3421962 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IVP17_RS16690 3421985..3425134 + 3150 WP_001132508.1 multidrug efflux RND transporter permease subunit -
IVP17_RS16695 3425630..3426004 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
IVP17_RS16700 3426032..3426250 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
IVP17_RS16705 3426429..3426980 + 552 WP_001278793.1 maltose O-acetyltransferase -
IVP17_RS16710 3427098..3427568 + 471 WP_000136181.1 membrane protein -
IVP17_RS16715 3427624..3427764 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
IVP17_RS16720 3427770..3428030 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
IVP17_RS16725 3428255..3429805 + 1551 WP_023210786.1 EAL domain-containing protein -
IVP17_RS16735 3430036..3430425 + 390 WP_000961285.1 MGMT family protein -
IVP17_RS16740 3430458..3431027 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T181322 WP_001280991.1 NZ_CP064663:3426032-3426250 [Salmonella sp. SJTUF14170]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T181322 NZ_CP085819:4016905-4017008 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT181322 WP_000344807.1 NZ_CP064663:3425630-3426004 [Salmonella sp. SJTUF14170]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT181322 NZ_CP085819:c4017010-4016865 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References