Detailed information of TA system TA181321

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2448965..2449487
• Replicon: chromosome
• Accession: NZ_CP064663
• Organism: Salmonella sp. SJTUF14170

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: B5F5Y5
• Locus tag: IVP17_RS11890
• Protein ID: WP_000221343.1
• Coordinates: 2449203..2449487 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: IVP17_RS11885
• Protein ID: WP_000885424.1
• Coordinates: 2448965..2449213 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVP17_RS11865	2444607..2446073	+	1467	WP_023893409.1	hypothetical protein	-
IVP17_RS11870	2446690..2446938	+	249	Protein_2322	helix-turn-helix domain-containing protein	-
IVP17_RS11875	2447049..2447957	-	909	WP_077910000.1	hypothetical protein	-
IVP17_RS11880	2448108..2448440	-	333	WP_023227504.1	DUF1493 family protein	-
IVP17_RS11885	2448965..2449213	+	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IVP17_RS11890	2449203..2449487	+	285	WP_000221343.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IVP17_RS11895	2449535..2449735	+	201	Protein_2327	RidA family protein	-
IVP17_RS11900	2449787..2450866	-	1080	WP_023227502.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
IVP17_RS11905	2451059..2451547	-	489	WP_023227501.1	MarR family winged helix-turn-helix transcriptional regulator	-
IVP17_RS11910	2451592..2453100	+	1509	WP_023227500.1	FAD-dependent oxidoreductase	-
IVP17_RS11915	2453090..2454331	+	1242	WP_023227499.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2446122..2455957	9835

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11075.85 Da
• Isoelectric Point: 10.6500

>T181321 WP_000221343.1 NZ_CP064663:2449203-2449487 [Salmonella sp. SJTUF14170]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Nucleotide

• Length: 285 bp

>T181321 NZ_CP085819:c2889975-2889448 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT181321 WP_000885424.1 NZ_CP064663:2448965-2449213 [Salmonella sp. SJTUF14170]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT181321 NZ_CP085819:c2890262-2889972 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Toxin

• AlphaFold DB: A0A5H5JSW4

Antitoxin

• AlphaFold DB: A0A5I0WPN5