Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1960229..1960819 Replicon chromosome
Accession NZ_CP064663
Organism Salmonella sp. SJTUF14170

Toxin (Protein)


Gene name pemK Uniprot ID V1H1P0
Locus tag IVP17_RS09400 Protein ID WP_023183318.1
Coordinates 1960487..1960819 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A5U2MUC8
Locus tag IVP17_RS09395 Protein ID WP_064001200.1
Coordinates 1960229..1960486 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP17_RS09375 1955924..1956736 + 813 WP_064001197.1 restriction endonuclease -
IVP17_RS09380 1956886..1958841 - 1956 WP_064163387.1 hypothetical protein -
IVP17_RS09385 1958912..1959677 + 766 Protein_1835 ash family protein -
IVP17_RS09390 1959674..1959880 + 207 WP_062872075.1 helix-turn-helix domain-containing protein -
IVP17_RS09395 1960229..1960486 + 258 WP_064001200.1 hypothetical protein Antitoxin
IVP17_RS09400 1960487..1960819 + 333 WP_023183318.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IVP17_RS09405 1961669..1962553 + 885 WP_064001202.1 integrase domain-containing protein -
IVP17_RS09410 1963350..1964612 - 1263 Protein_1840 tyrosine-type recombinase/integrase -
IVP17_RS09420 1964950..1965747 - 798 WP_000598921.1 DgsA anti-repressor MtfA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11844.64 Da        Isoelectric Point: 9.3417

>T181312 WP_023183318.1 NZ_CP064663:1960487-1960819 [Salmonella sp. SJTUF14170]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNTFTRLPVVVPVTSGGNFAREAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPEAIVNEVLARLEAILS

Download         Length: 333 bp

>T181312 NZ_CP085819:c1248918-1248634 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9414.86 Da        Isoelectric Point: 4.4488

>AT181312 WP_064001200.1 NZ_CP064663:1960229-1960486 [Salmonella sp. SJTUF14170]
MYTTRLKKVGGSVMLAVPPAVLKTLGLSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPTV
GREIL

Download         Length: 258 bp

>AT181312 NZ_CP085819:c1249150-1248908 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V1H1P0

Antitoxin

Source ID Structure
AlphaFold DB A0A5U2MUC8

References