Detailed information of TA system TA181311

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 999533..1000347
• Replicon: chromosome
• Accession: NZ_CP064663
• Organism: Salmonella sp. SJTUF14170

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: Q57KM2
• Locus tag: IVP17_RS04840
• Protein ID: WP_000971655.1
• Coordinates: 999533..1000060 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: A0A4Y6M833
• Locus tag: IVP17_RS04845
• Protein ID: WP_072162154.1
• Coordinates: 1000057..1000347 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVP17_RS04810	995834..996232	+	399	Protein_941	cytoplasmic protein	-
IVP17_RS04815	996443..996610	+	168	Protein_942	transposase	-
IVP17_RS04820	996818..997486	+	669	WP_000445914.1	hypothetical protein	-
IVP17_RS04825	997513..998007	+	495	WP_023227564.1	hypothetical protein	-
IVP17_RS04830	998252..998908	-	657	WP_000420452.1	protein-serine/threonine phosphatase	-
IVP17_RS04835	999237..999460	+	224	Protein_946	IS5/IS1182 family transposase	-
IVP17_RS04840	999533..1000060	-	528	WP_000971655.1	GNAT family N-acetyltransferase	Toxin
IVP17_RS04845	1000057..1000347	-	291	WP_072162154.1	DUF1778 domain-containing protein	Antitoxin
IVP17_RS04850	1000617..1000795	-	179	Protein_949	IS3 family transposase	-
IVP17_RS04855	1001036..1001362	+	327	WP_000393302.1	hypothetical protein	-
IVP17_RS04860	1001635..1001982	-	348	WP_001669174.1	DUF1493 family protein	-
IVP17_RS04865	1001967..1002416	-	450	WP_000381610.1	membrane protein	-
IVP17_RS04870	1002847..1003290	-	444	WP_000715096.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
IVP17_RS04875	1003746..1004396	+	651	WP_001674874.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	999320..1009709	10389
	-	flank	IS/Tn	-	-	999320..999460	140

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19069.91 Da
• Isoelectric Point: 9.6420

>T181311 WP_000971655.1 NZ_CP064663:c1000060-999533 [Salmonella sp. SJTUF14170]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T181311 NZ_CP085819:c1154948-1154661 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.54 Da
• Isoelectric Point: 8.5779

>AT181311 WP_072162154.1 NZ_CP064663:c1000347-1000057 [Salmonella sp. SJTUF14170]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT181311 NZ_CP085819:c1154674-1154372 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Structures

Toxin

• PDB: 6G96
• PDB: 7AK9

Antitoxin

• AlphaFold DB: A0A4Y6M833