Detailed information of TA system TA181310

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 850774..851399
• Replicon: chromosome
• Accession: NZ_CP064663
• Organism: Salmonella sp. SJTUF14170

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IVP17_RS04170
• Protein ID: WP_000911337.1
• Coordinates: 851001..851399 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C0PXM4
• Locus tag: IVP17_RS04165
• Protein ID: WP_000557545.1
• Coordinates: 850774..851001 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVP17_RS04135	845819..847336	+	1518	WP_000003339.1	lysine--tRNA ligase	-
IVP17_RS04140	847412..847957	-	546	WP_000133994.1	isopentenyl-diphosphate Delta-isomerase	-
IVP17_RS04145	848222..848980	+	759	WP_000244318.1	peptidoglycan DD-metalloendopeptidase family protein	-
IVP17_RS04155	849265..850071	-	807	WP_010989071.1	DUF1460 domain-containing protein	-
IVP17_RS04160	850346..850606	-	261	WP_023227725.1	hypothetical protein	-
IVP17_RS04165	850774..851001	+	228	WP_000557545.1	toxin-antitoxin system antitoxin VapB	Antitoxin
IVP17_RS04170	851001..851399	+	399	WP_000911337.1	tRNA(fMet)-specific endonuclease VapC	Toxin
IVP17_RS04175	852203..852739	+	537	WP_023227726.1	STM3031 family outer membrane protein	-
IVP17_RS04180	852786..853418	+	633	WP_023227727.1	YfdX family protein	-
IVP17_RS04185	854137..854718	+	582	WP_064163437.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	849265..860587	11322

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15037.43 Da
• Isoelectric Point: 7.7785

>T181310 WP_000911337.1 NZ_CP064663:851001-851399 [Salmonella sp. SJTUF14170]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Nucleotide

• Length: 399 bp

>T181310 NZ_CP085819:742896-743171 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8500.48 Da
• Isoelectric Point: 5.0053

>AT181310 WP_000557545.1 NZ_CP064663:850774-851001 [Salmonella sp. SJTUF14170]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Nucleotide

• Length: 228 bp

>AT181310 NZ_CP085819:c743161-742739 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Antitoxin

• AlphaFold DB: A0A0R9MGW6