Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 839887..840547 Replicon chromosome
Accession NZ_CP064663
Organism Salmonella sp. SJTUF14170

Toxin (Protein)


Gene name cptA Uniprot ID A0A3V4SJP5
Locus tag IVP17_RS04105 Protein ID WP_000244755.1
Coordinates 840134..840547 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag IVP17_RS04100 Protein ID WP_000351186.1
Coordinates 839887..840153 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP17_RS04080 836196..836507 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
IVP17_RS04085 836671..837330 + 660 WP_000250289.1 hemolysin III family protein -
IVP17_RS04090 837588..838574 + 987 WP_023226548.1 IS110 family transposase -
IVP17_RS04095 838657..839637 - 981 WP_017441090.1 tRNA-modifying protein YgfZ -
IVP17_RS04100 839887..840153 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
IVP17_RS04105 840134..840547 + 414 WP_000244755.1 protein YgfX Toxin
IVP17_RS04110 840600..841121 - 522 WP_001055885.1 flavodoxin FldB -
IVP17_RS04115 841234..842130 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
IVP17_RS04120 842154..842867 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IVP17_RS04125 842873..844606 + 1734 WP_023227724.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16164.10 Da        Isoelectric Point: 10.2118

>T181309 WP_000244755.1 NZ_CP064663:840134-840547 [Salmonella sp. SJTUF14170]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLHPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T181309 NZ_CP085819:541648-541866 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT181309 WP_000351186.1 NZ_CP064663:839887-840153 [Salmonella sp. SJTUF14170]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT181309 NZ_CP085819:541246-541620 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SJP5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References