Detailed information of TA system TA181307

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 4618718..4619334
• Replicon: chromosome
• Accession: NZ_CP064661
• Organism: Salmonella sp. SJTUF14178

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IVP18_RS22325
• Protein ID: WP_064163215.1
• Coordinates: 4618718..4619092 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8E9YHE9
• Locus tag: IVP18_RS22330
• Protein ID: WP_001523745.1
• Coordinates: 4619092..4619334 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVP18_RS22310	4616220..4617122	+	903	WP_051129234.1	formate dehydrogenase subunit beta	-
IVP18_RS22315	4617119..4617754	+	636	WP_000829028.1	formate dehydrogenase cytochrome b556 subunit	-
IVP18_RS22320	4617751..4618680	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
IVP18_RS22325	4618718..4619092	-	375	WP_064163215.1	type II toxin-antitoxin system VapC family toxin	Toxin
IVP18_RS22330	4619092..4619334	-	243	WP_001523745.1	ribbon-helix-helix domain-containing protein	Antitoxin
IVP18_RS22335	4619539..4620468	+	930	WP_001162861.1	alpha/beta hydrolase	-
IVP18_RS22340	4620554..4620865	+	312	WP_000558165.1	type II toxin-antitoxin system HigB family toxin	-
IVP18_RS22345	4620862..4621308	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
IVP18_RS22350	4621323..4622264	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
IVP18_RS22355	4622309..4622746	-	438	WP_000560969.1	D-tyrosyl-tRNA(Tyr) deacylase	-
IVP18_RS22360	4622743..4623615	-	873	WP_000921423.1	virulence factor BrkB family protein	-
IVP18_RS22365	4623609..4624208	-	600	WP_023227076.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (13-47)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13942.20 Da
• Isoelectric Point: 7.3567

>T181307 WP_064163215.1 NZ_CP064661:c4619092-4618718 [Salmonella sp. SJTUF14178]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHF

Nucleotide

• Length: 375 bp

>T181307 NZ_CP085818:c4256244-4255876 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9437.77 Da
• Isoelectric Point: 4.4463

>AT181307 WP_001523745.1 NZ_CP064661:c4619334-4619092 [Salmonella sp. SJTUF14178]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Nucleotide

• Length: 243 bp

>AT181307 NZ_CP085818:c4256462-4256241 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA