Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4152822..4153338 Replicon chromosome
Accession NZ_CP064661
Organism Salmonella sp. SJTUF14178

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag IVP18_RS20130 Protein ID WP_000220577.1
Coordinates 4152822..4153106 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag IVP18_RS20135 Protein ID WP_000212724.1
Coordinates 4153096..4153338 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP18_RS20115 4147938..4149590 + 1653 WP_000155050.1 alpha,alpha-phosphotrehalase -
IVP18_RS20120 4149999..4152137 + 2139 WP_023226981.1 anaerobic ribonucleoside-triphosphate reductase -
IVP18_RS20125 4152354..4152818 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IVP18_RS20130 4152822..4153106 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IVP18_RS20135 4153096..4153338 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IVP18_RS20140 4153416..4155329 - 1914 WP_023226980.1 BglG family transcription antiterminator -
IVP18_RS20145 4155346..4156086 - 741 WP_000779254.1 KDGP aldolase family protein -
IVP18_RS20150 4156083..4157201 - 1119 WP_023137277.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
IVP18_RS20155 4157185..4158318 - 1134 WP_023226979.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T181306 WP_000220577.1 NZ_CP064661:c4153106-4152822 [Salmonella sp. SJTUF14178]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T181306 NZ_CP085818:c4207825-4207550 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT181306 WP_000212724.1 NZ_CP064661:c4153338-4153096 [Salmonella sp. SJTUF14178]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT181306 NZ_CP085818:c4208088-4207828 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References