Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3425691..3426311 Replicon chromosome
Accession NZ_CP064661
Organism Salmonella sp. SJTUF14178

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag IVP18_RS16700 Protein ID WP_001280991.1
Coordinates 3426093..3426311 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag IVP18_RS16695 Protein ID WP_000344807.1
Coordinates 3425691..3426065 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP18_RS16685 3420830..3422023 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IVP18_RS16690 3422046..3425195 + 3150 WP_001132508.1 multidrug efflux RND transporter permease subunit -
IVP18_RS16695 3425691..3426065 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
IVP18_RS16700 3426093..3426311 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
IVP18_RS16705 3426490..3427041 + 552 WP_001278793.1 maltose O-acetyltransferase -
IVP18_RS16710 3427159..3427629 + 471 WP_000136181.1 membrane protein -
IVP18_RS16715 3427685..3427825 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
IVP18_RS16720 3427831..3428091 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
IVP18_RS16725 3428316..3429866 + 1551 WP_023210786.1 EAL domain-containing protein -
IVP18_RS16735 3430097..3430486 + 390 WP_000961285.1 MGMT family protein -
IVP18_RS16740 3430519..3431088 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T181302 WP_001280991.1 NZ_CP064661:3426093-3426311 [Salmonella sp. SJTUF14178]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T181302 NZ_CP085818:2091249-2091404 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT181302 WP_000344807.1 NZ_CP064661:3425691-3426065 [Salmonella sp. SJTUF14178]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT181302 NZ_CP085818:c2091237-2091179 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References