Detailed information of TA system TA181284

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3704762..3705419
• Replicon: chromosome
• Accession: NZ_CP064656
• Organism: Enterobacter hormaechei strain 3804

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: IT786_RS17720
• Protein ID: WP_058652631.1
• Coordinates: 3704762..3705172 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: G8LDB7
• Locus tag: IT786_RS17725
• Protein ID: WP_003863437.1
• Coordinates: 3705153..3705419 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IT786_RS17700	3700760..3702493	-	1734	WP_003863445.1	single-stranded-DNA-specific exonuclease RecJ	-
IT786_RS17705	3702499..3703212	-	714	WP_003863443.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
IT786_RS17710	3703241..3704137	-	897	WP_003863442.1	site-specific tyrosine recombinase XerD	-
IT786_RS17715	3704239..3704760	+	522	WP_003863440.1	flavodoxin FldB	-
IT786_RS17720	3704762..3705172	-	411	WP_058652631.1	protein YgfX	Toxin
IT786_RS17725	3705153..3705419	-	267	WP_003863437.1	FAD assembly factor SdhE	Antitoxin
IT786_RS17730	3705714..3706694	+	981	WP_003863435.1	tRNA-modifying protein YgfZ	-
IT786_RS17735	3706780..3707439	-	660	WP_003863433.1	hemolysin III family protein	-
IT786_RS17740	3707706..3708437	+	732	WP_003863431.1	MurR/RpiR family transcriptional regulator	-
IT786_RS17745	3708554..3709987	+	1434	WP_003863430.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16367.25 Da
• Isoelectric Point: 11.6602

>T181284 WP_058652631.1 NZ_CP064656:c3705172-3704762 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIRLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Nucleotide

• Length: 411 bp

>T181284 NZ_CP085817:1119185-1119493 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10526.96 Da
• Isoelectric Point: 4.8310

>AT181284 WP_003863437.1 NZ_CP064656:c3705419-3705153 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Nucleotide

• Length: 267 bp

>AT181284 NZ_CP085817:1118943-1119182 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A837F8P5