Detailed information of TA system TA181283

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA(toxin)
• Location: 3027676..3029459
• Replicon: chromosome
• Accession: NZ_CP064656
• Organism: Enterobacter hormaechei strain 3804

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: IT786_RS14605
• Protein ID: WP_058652848.1
• Coordinates: 3027676..3029025 (+)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A837FFV9
• Locus tag: IT786_RS14610
• Protein ID: WP_003859317.1
• Coordinates: 3029022..3029459 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IT786_RS14580	3023499..3024434	-	936	WP_003859306.1	tRNA dihydrouridine(16) synthase DusC	-
IT786_RS14585	3024603..3024998	+	396	WP_003859308.1	CidA/LrgA family protein	-
IT786_RS14590	3024995..3025690	+	696	WP_003859310.1	CidB/LrgB family autolysis modulator	-
IT786_RS14595	3025819..3026703	+	885	WP_003859312.1	cytidine deaminase	-
IT786_RS14600	3026831..3027541	+	711	WP_003859314.1	outer membrane permeability protein SanA	-
IT786_RS14605	3027676..3029025	+	1350	WP_058652848.1	type II toxin-antitoxin system HipA family toxin	Toxin
IT786_RS14610	3029022..3029459	+	438	WP_003859317.1	helix-turn-helix domain-containing protein	Antitoxin
IT786_RS14615	3029498..3030508	-	1011	WP_003859318.1	galactose/methyl galactoside ABC transporter permease MglC	-
IT786_RS14620	3030524..3032044	-	1521	WP_003859320.1	galactose/methyl galactoside ABC transporter ATP-binding protein MglA	-
IT786_RS14625	3032124..3033122	-	999	WP_017383382.1	galactose/glucose ABC transporter substrate-binding protein MglB	-
IT786_RS14630	3033418..3034440	-	1023	WP_003859324.1	HTH-type transcriptional regulator GalS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-406)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 51151.81 Da
• Isoelectric Point: 4.6562

>T181283 WP_058652848.1 NZ_CP064656:3027676-3029025 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESIPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHEINAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Nucleotide

• Length: 1350 bp

>T181283 NZ_CP085817:1078084-1078368 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 16185.64 Da
• Isoelectric Point: 10.5154

>AT181283 WP_003859317.1 NZ_CP064656:3029022-3029459 [Enterobacter hormaechei]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Nucleotide

• Length: 438 bp

>AT181283 NZ_CP085817:1077852-1078094 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A837FFV9