Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1057824..1058444 Replicon chromosome
Accession NZ_CP064656
Organism Enterobacter hormaechei strain 3804

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag IT786_RS05040 Protein ID WP_015571250.1
Coordinates 1057824..1058042 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag IT786_RS05045 Protein ID WP_006809850.1
Coordinates 1058070..1058444 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT786_RS05010 1053836..1054096 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
IT786_RS05015 1054099..1054239 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
IT786_RS05020 1054236..1054946 - 711 WP_022650493.1 GNAT family N-acetyltransferase -
IT786_RS05025 1055048..1056508 + 1461 WP_058652690.1 PLP-dependent aminotransferase family protein -
IT786_RS05030 1056480..1056947 - 468 WP_022650495.1 hypothetical protein -
IT786_RS05035 1057064..1057615 - 552 WP_022650496.1 maltose O-acetyltransferase -
IT786_RS05040 1057824..1058042 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
IT786_RS05045 1058070..1058444 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
IT786_RS05050 1058955..1062101 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit -
IT786_RS05055 1062124..1063317 - 1194 WP_058652691.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T181273 WP_015571250.1 NZ_CP064656:c1058042-1057824 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T181273 NZ_CP085816:4058490-4058801 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT181273 WP_006809850.1 NZ_CP064656:c1058444-1058070 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT181273 NZ_CP085816:4058798-4059244 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References