Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-StbC
Location 3006395..3007037 Replicon chromosome
Accession NZ_CP064653
Organism Methylomonas sp. LL1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IVG45_RS13940 Protein ID WP_196434413.1
Coordinates 3006618..3007037 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IVG45_RS13935 Protein ID WP_196434412.1
Coordinates 3006395..3006631 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVG45_RS13910 3002106..3002816 + 711 WP_196434407.1 hypothetical protein -
IVG45_RS13915 3002938..3003846 + 909 WP_196434408.1 hypothetical protein -
IVG45_RS13920 3003999..3004337 + 339 WP_196434409.1 hypothetical protein -
IVG45_RS13925 3004572..3004853 + 282 WP_196434410.1 hypothetical protein -
IVG45_RS13930 3004897..3006123 + 1227 WP_196434411.1 IS256 family transposase -
IVG45_RS13935 3006395..3006631 + 237 WP_196434412.1 DNA-binding protein Antitoxin
IVG45_RS13940 3006618..3007037 + 420 WP_196434413.1 type II toxin-antitoxin system VapC family toxin Toxin
IVG45_RS13945 3007274..3007525 - 252 Protein_2646 ISNCY family transposase -
IVG45_RS13950 3007950..3008456 + 507 WP_196434414.1 hypothetical protein -
IVG45_RS13955 3008747..3010189 - 1443 WP_196434415.1 FAD-dependent oxidoreductase -
IVG45_RS13960 3010474..3011910 - 1437 WP_196434416.1 pyruvate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3004897..3007525 2628


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15790.12 Da        Isoelectric Point: 5.1661

>T181270 WP_196434413.1 NZ_CP064653:3006618-3007037 [Methylomonas sp. LL1]
MYLIDTNVISEIRKGDKANLGVRRFFDAATQNNQKLYISVVTIGELRRGVDLIFHRGDISQSKLLETWLNSILEQYQENI
LGIDCEIALIWGKMRVPNPQHPIDKLIAATALIYDLTVVTRNTDDFQNTGIALLNPFSE

Download         Length: 420 bp

>T181270 NZ_CP085816:c3640833-3640549 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8645.77 Da        Isoelectric Point: 6.2096

>AT181270 WP_196434412.1 NZ_CP064653:3006395-3006631 [Methylomonas sp. LL1]
MPSLVVRNLDESIINALKARAVAHHRSTEAEHRAILAEFLLSPQRKTFAEALANIPSVGIDSDFQRVNDNTMATNVFD

Download         Length: 237 bp

>AT181270 NZ_CP085816:c3641065-3640823 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References