Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 216845..217374 Replicon chromosome
Accession NZ_CP064424
Organism Enterococcus faecium strain PR01996-12

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag IUH71_RS01070 Protein ID WP_002296560.1
Coordinates 217108..217374 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag IUH71_RS01065 Protein ID WP_002296559.1
Coordinates 216845..217108 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUH71_RS01055 (IUH71_01055) 214219..216042 + 1824 WP_002294202.1 APC family permease -
IUH71_RS01060 (IUH71_01060) 216184..216369 - 186 WP_002296558.1 transcriptional regulator -
IUH71_RS01065 (IUH71_01065) 216845..217108 + 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IUH71_RS01070 (IUH71_01070) 217108..217374 + 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
IUH71_RS01075 (IUH71_01075) 217575..218063 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
IUH71_RS01080 (IUH71_01080) 218604..219275 - 672 WP_002302663.1 ABC transporter permease -
IUH71_RS01085 (IUH71_01085) 219272..220189 - 918 WP_002296564.1 osmoprotectant ABC transporter substrate-binding protein -
IUH71_RS01090 (IUH71_01090) 220186..220827 - 642 WP_002293405.1 ABC transporter permease -
IUH71_RS01095 (IUH71_01095) 220831..222006 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T181264 WP_002296560.1 NZ_CP064424:217108-217374 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T181264 NZ_CP085816:c2012023-2011868 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT181264 WP_002296559.1 NZ_CP064424:216845-217108 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp

>AT181264 NZ_CP085816:2012035-2012093 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References