Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 183801..184330 Replicon chromosome
Accession NZ_CP064406
Organism Enterococcus faecium strain PR05720-3

Toxin (Protein)


Gene name relE Uniprot ID A0A2D0BMD7
Locus tag IUH68_RS00920 Protein ID WP_002319468.1
Coordinates 184064..184330 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag IUH68_RS00915 Protein ID WP_002294199.1
Coordinates 183801..184064 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUH68_RS00905 (IUH68_00905) 181176..182999 + 1824 WP_002294202.1 APC family permease -
IUH68_RS00910 (IUH68_00910) 183141..183326 - 186 WP_002294201.1 hypothetical protein -
IUH68_RS00915 (IUH68_00915) 183801..184064 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IUH68_RS00920 (IUH68_00920) 184064..184330 + 267 WP_002319468.1 Txe/YoeB family addiction module toxin Toxin
IUH68_RS00925 (IUH68_00925) 184531..185019 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
IUH68_RS00930 (IUH68_00930) 185561..186232 - 672 WP_002319469.1 ABC transporter permease -
IUH68_RS00935 (IUH68_00935) 186229..187146 - 918 WP_002319470.1 osmoprotectant ABC transporter substrate-binding protein -
IUH68_RS00940 (IUH68_00940) 187143..187784 - 642 WP_002319471.1 ABC transporter permease -
IUH68_RS00945 (IUH68_00945) 187788..188963 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.08 Da        Isoelectric Point: 9.9931

>T181262 WP_002319468.1 NZ_CP064406:184064-184330 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVAEI
YSAWTHYE

Download         Length: 267 bp

>T181262 NZ_CP085816:370421-370819 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT181262 WP_002294199.1 NZ_CP064406:183801-184064 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT181262 NZ_CP085816:370194-370421 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2D0BMD7

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References