Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2887589..2888303 Replicon chromosome
Accession NZ_CP064405
Organism Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag IRY56_RS13325 Protein ID WP_003413460.1
Coordinates 2887863..2888303 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag IRY56_RS13320 Protein ID WP_003413456.1
Coordinates 2887589..2887876 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRY56_RS13285 2883021..2883266 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
IRY56_RS13290 2883263..2883667 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
IRY56_RS13295 2883884..2884504 + 621 WP_003413441.1 DUF4178 domain-containing protein -
IRY56_RS13300 2884515..2885009 + 495 WP_003413444.1 DUF2617 family protein -
IRY56_RS13305 2885006..2885437 + 432 WP_003413445.1 DUF4247 domain-containing protein -
IRY56_RS13310 2885462..2885910 + 449 Protein_2627 DUF350 domain-containing protein -
IRY56_RS13315 2885907..2887478 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
IRY56_RS13320 2887589..2887876 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
IRY56_RS13325 2887863..2888303 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
IRY56_RS13330 2888324..2889079 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
IRY56_RS13335 2889212..2889808 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
IRY56_RS13340 2889816..2890661 - 846 WP_010950749.1 acyl-CoA thioesterase II -
IRY56_RS13345 2890690..2891589 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
IRY56_RS13350 2891717..2892391 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T181249 WP_003413460.1 NZ_CP064405:2887863-2888303 [Mycobacterium tuberculosis variant bovis BCG]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T181249 NZ_CP085815:2436778-2437035 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT181249 WP_003413456.1 NZ_CP064405:2887589-2887876 [Mycobacterium tuberculosis variant bovis BCG]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT181249 NZ_CP085815:c2436953-2436621 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References