Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 2826131..2826762 | Replicon | chromosome |
Accession | NZ_CP064405 | ||
Organism | Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQ28 |
Locus tag | IRY56_RS13050 | Protein ID | WP_003413174.1 |
Coordinates | 2826385..2826762 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P95006 |
Locus tag | IRY56_RS13045 | Protein ID | WP_003413167.1 |
Coordinates | 2826131..2826388 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IRY56_RS13010 | 2821389..2821703 | + | 315 | WP_009937839.1 | hypothetical protein | - |
IRY56_RS13015 | 2821999..2823210 | + | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
IRY56_RS13020 | 2823337..2823996 | + | 660 | WP_003900846.1 | LppA family lipoprotein | - |
IRY56_RS13025 | 2823993..2824652 | + | 660 | WP_003900847.1 | hypothetical protein | - |
IRY56_RS13030 | 2824649..2825311 | + | 663 | WP_003900848.1 | hypothetical protein | - |
IRY56_RS13035 | 2825308..2825586 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
IRY56_RS13040 | 2825679..2826092 | + | 414 | WP_003413164.1 | PIN domain nuclease | - |
IRY56_RS13045 | 2826131..2826388 | + | 258 | WP_003413167.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
IRY56_RS13050 | 2826385..2826762 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
IRY56_RS13055 | 2826778..2827152 | - | 375 | WP_003413177.1 | hypothetical protein | - |
IRY56_RS13060 | 2827252..2827647 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
IRY56_RS13065 | 2827644..2827889 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
IRY56_RS13070 | 2828300..2828719 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
IRY56_RS13075 | 2828731..2829558 | - | 828 | WP_010950736.1 | shikimate dehydrogenase | - |
IRY56_RS13080 | 2829536..2830789 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
IRY56_RS13085 | 2830782..2831294 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13728.72 Da Isoelectric Point: 4.4687
>T181247 WP_003413174.1 NZ_CP064405:2826385-2826762 [Mycobacterium tuberculosis variant bovis BCG]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
Download Length: 378 bp
>T181247 NZ_CP085815:c1527910-1527807 [Salmonella enterica subsp. enterica serovar Enteritidis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 86 a.a. Molecular weight: 9453.63 Da Isoelectric Point: 10.6555
>AT181247 WP_003413167.1 NZ_CP064405:2826131-2826388 [Mycobacterium tuberculosis variant bovis BCG]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT181247 NZ_CP085815:1527805-1527950 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQ28 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829C9W5 |