Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2375274..2375803 Replicon chromosome
Accession NZ_CP064405
Organism Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag IRY56_RS10940 Protein ID WP_003411124.1
Coordinates 2375274..2375591 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag IRY56_RS10945 Protein ID WP_003411127.1
Coordinates 2375588..2375803 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRY56_RS10910 2370411..2371487 + 1077 WP_003411110.1 hypothetical protein -
IRY56_RS10915 2371484..2371765 + 282 WP_019283661.1 hypothetical protein -
IRY56_RS10920 2371801..2372874 + 1074 WP_011799246.1 quinone-dependent dihydroorotate dehydrogenase -
IRY56_RS10925 2372879..2373409 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
IRY56_RS10930 2373457..2374803 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
IRY56_RS10940 2375274..2375591 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IRY56_RS10945 2375588..2375803 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
IRY56_RS10950 2376058..2377116 + 1059 WP_003411129.1 hypothetical protein -
IRY56_RS10955 2377246..2377602 - 357 WP_003411130.1 hypothetical protein -
IRY56_RS10960 2377697..2378479 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
IRY56_RS10965 2378747..2379037 - 291 WP_003900476.1 YggT family protein -
IRY56_RS10970 2379199..2379855 - 657 WP_003411133.1 cell division protein SepF -
IRY56_RS10975 2379921..2380697 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T181243 WP_003411124.1 NZ_CP064405:c2375591-2375274 [Mycobacterium tuberculosis variant bovis BCG]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T181243 NZ_CP085814:4195539-4196066 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT181243 WP_003411127.1 NZ_CP064405:c2375803-2375588 [Mycobacterium tuberculosis variant bovis BCG]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT181243 NZ_CP085814:4195252-4195542 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References