Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2338610..2339305 Replicon chromosome
Accession NZ_CP064405
Organism Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag IRY56_RS10740 Protein ID WP_003410811.1
Coordinates 2338610..2339044 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag IRY56_RS10745 Protein ID WP_003410814.1
Coordinates 2339051..2339305 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRY56_RS10730 2334764..2337805 + 3042 WP_010950658.1 DEAD/DEAH box helicase -
IRY56_RS10735 2337798..2338631 + 834 WP_003899172.1 SWIM zinc finger family protein -
IRY56_RS10740 2338610..2339044 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
IRY56_RS10745 2339051..2339305 - 255 WP_003410814.1 antitoxin Antitoxin
IRY56_RS10750 2339321..2339578 - 258 WP_003410816.1 hypothetical protein -
IRY56_RS10755 2340525..2340821 + 297 WP_003410820.1 PE family protein -
IRY56_RS10760 2340877..2341608 + 732 WP_003900467.1 PPE family protein -
IRY56_RS10765 2342148..2342894 - 747 WP_003901330.1 proteasome subunit alpha -
IRY56_RS10770 2342891..2343766 - 876 WP_003411023.1 proteasome subunit beta -
IRY56_RS10775 2343763..2343957 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T181242 WP_003410811.1 NZ_CP064405:c2339044-2338610 [Mycobacterium tuberculosis variant bovis BCG]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T181242 NZ_CP085814:2706801-2706956 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT181242 WP_003410814.1 NZ_CP064405:c2339305-2339051 [Mycobacterium tuberculosis variant bovis BCG]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT181242 NZ_CP085814:c2706789-2706731 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References