Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2204470..2205368 Replicon chromosome
Accession NZ_CP064405
Organism Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag IRY56_RS10150 Protein ID WP_003410001.1
Coordinates 2204470..2205030 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag IRY56_RS10155 Protein ID WP_003410003.1
Coordinates 2205027..2205368 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRY56_RS10120 2199639..2200292 - 654 WP_003409976.1 cutinase Cfp21 -
IRY56_RS10125 2200407..2200637 + 231 WP_003409980.1 DUF167 domain-containing protein -
IRY56_RS10130 2200722..2201633 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
IRY56_RS10135 2201742..2202341 + 600 WP_003409989.1 L-lysine exporter -
IRY56_RS10140 2202757..2203185 + 429 WP_003409992.1 cellulose-binding protein -
IRY56_RS10145 2203411..2203950 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
IRY56_RS10150 2204470..2205030 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
IRY56_RS10155 2205027..2205368 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
IRY56_RS10160 2205454..2205711 + 258 WP_003410006.1 hypothetical protein -
IRY56_RS10165 2205612..2205947 - 336 WP_003410009.1 dehydrogenase -
IRY56_RS10170 2206036..2206380 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
IRY56_RS10175 2206374..2206622 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
IRY56_RS10180 2206722..2209037 - 2316 WP_003899120.1 cation transporter ATPase CptG -
IRY56_RS10185 2209034..2209306 - 273 WP_003410017.1 DUF1490 family protein -
IRY56_RS10190 2209359..2209715 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T181237 WP_003410001.1 NZ_CP064405:c2205030-2204470 [Mycobacterium tuberculosis variant bovis BCG]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T181237 NZ_CP085814:1119095-1119403 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT181237 WP_003410003.1 NZ_CP064405:c2205368-2205027 [Mycobacterium tuberculosis variant bovis BCG]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT181237 NZ_CP085814:1118853-1119092 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References