Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2197144..2197832 Replicon chromosome
Accession NZ_CP064405
Organism Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag IRY56_RS10105 Protein ID WP_003409958.1
Coordinates 2197144..2197563 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag IRY56_RS10110 Protein ID WP_003409968.1
Coordinates 2197572..2197832 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRY56_RS10080 2192150..2192455 + 306 Protein_1991 ABC transporter permease -
IRY56_RS10085 2192639..2193487 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
IRY56_RS10090 2193450..2194895 - 1446 WP_003409946.1 APC family permease -
IRY56_RS10095 2195074..2195760 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
IRY56_RS10100 2195951..2196919 - 969 WP_003409956.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
IRY56_RS10105 2197144..2197563 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
IRY56_RS10110 2197572..2197832 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IRY56_RS10115 2197975..2199651 + 1677 WP_010950639.1 PecA family PE domain-processing aspartic protease -
IRY56_RS10120 2199639..2200292 - 654 WP_003409976.1 cutinase Cfp21 -
IRY56_RS10125 2200407..2200637 + 231 WP_003409980.1 DUF167 domain-containing protein -
IRY56_RS10130 2200722..2201633 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
IRY56_RS10135 2201742..2202341 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T181236 WP_003409958.1 NZ_CP064405:c2197563-2197144 [Mycobacterium tuberculosis variant bovis BCG]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T181236 NZ_CP085814:1077977-1078261 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT181236 WP_003409968.1 NZ_CP064405:c2197832-2197572 [Mycobacterium tuberculosis variant bovis BCG]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT181236 NZ_CP085814:1077745-1077987 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References