Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2188130..2188674 Replicon chromosome
Accession NZ_CP064405
Organism Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag IRY56_RS10050 Protein ID WP_003409896.1
Coordinates 2188130..2188426 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag IRY56_RS10055 Protein ID WP_003409899.1
Coordinates 2188423..2188674 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRY56_RS09995 2183163..2183513 - 351 WP_003409871.1 hypothetical protein -
IRY56_RS10000 2183524..2184426 - 903 WP_003409874.1 hypothetical protein -
IRY56_RS10005 2184447..2184638 - 192 WP_003409876.1 hypothetical protein -
IRY56_RS10010 2184639..2184935 - 297 WP_003409877.1 hypothetical protein -
IRY56_RS10015 2185175..2185390 + 216 WP_003409878.1 antitoxin -
IRY56_RS10020 2185387..2185698 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
IRY56_RS10025 2185672..2186193 - 522 WP_010950637.1 hypothetical protein -
IRY56_RS10030 2186168..2186545 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
IRY56_RS10035 2186587..2187036 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
IRY56_RS10040 2187033..2187578 + 546 WP_003409891.1 SecB-like chaperone -
IRY56_RS10045 2187467..2188081 - 615 WP_003901296.1 hypothetical protein -
IRY56_RS10050 2188130..2188426 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IRY56_RS10055 2188423..2188674 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
IRY56_RS10060 2188661..2189155 + 495 WP_003899099.1 hypothetical protein -
IRY56_RS10065 2189315..2189722 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
IRY56_RS10070 2189726..2189998 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
IRY56_RS10075 2190031..2191251 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
IRY56_RS10080 2192150..2192455 + 306 Protein_1991 ABC transporter permease -
IRY56_RS10085 2192639..2193487 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T181235 WP_003409896.1 NZ_CP064405:c2188426-2188130 [Mycobacterium tuberculosis variant bovis BCG]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T181235 NZ_CP085814:970875-971366 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT181235 WP_003409899.1 NZ_CP064405:c2188674-2188423 [Mycobacterium tuberculosis variant bovis BCG]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT181235 NZ_CP085814:970585-970878 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References