Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1925446..1926059 Replicon chromosome
Accession NZ_CP064405
Organism Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag IRY56_RS08835 Protein ID WP_003408465.1
Coordinates 1925446..1925835 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag IRY56_RS08840 Protein ID WP_003408469.1
Coordinates 1925832..1926059 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRY56_RS08805 1921076..1921990 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
IRY56_RS08810 1921993..1922823 + 831 WP_003408448.1 cyclase family protein -
IRY56_RS08815 1922823..1923173 + 351 WP_003898986.1 cupin domain-containing protein -
IRY56_RS08820 1923226..1924043 + 818 Protein_1740 3-keto-5-aminohexanoate cleavage protein -
IRY56_RS08825 1924057..1924836 + 780 WP_003408460.1 IclR family transcriptional regulator -
IRY56_RS08835 1925446..1925835 - 390 WP_003408465.1 PIN domain-containing protein Toxin
IRY56_RS08840 1925832..1926059 - 228 WP_003408469.1 antitoxin Antitoxin
IRY56_RS08845 1926277..1927761 + 1485 WP_010950580.1 biotin carboxylase -
IRY56_RS08850 1927758..1929005 + 1248 WP_003408476.1 serine hydrolase -
IRY56_RS08855 1929048..1929467 - 420 WP_003408483.1 hypothetical protein -
IRY56_RS08860 1929457..1930167 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T181231 WP_003408465.1 NZ_CP064405:c1925835-1925446 [Mycobacterium tuberculosis variant bovis BCG]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T181231 NZ_CP085814:c160361-159993 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT181231 WP_003408469.1 NZ_CP064405:c1926059-1925832 [Mycobacterium tuberculosis variant bovis BCG]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT181231 NZ_CP085814:c160579-160358 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References