Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1538089..1539139 Replicon chromosome
Accession NZ_CP064405
Organism Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag IRY56_RS07155 Protein ID WP_003407164.1
Coordinates 1538089..1538910 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag IRY56_RS07160 Protein ID WP_003407167.1
Coordinates 1538903..1539139 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRY56_RS07135 1533647..1534309 - 663 WP_010950531.1 hypothetical protein -
IRY56_RS07140 1534306..1535091 - 786 WP_003407157.1 membrane protein -
IRY56_RS07145 1535382..1537343 - 1962 WP_010950533.1 sigma-F factor regulator -
IRY56_RS07150 1537482..1537868 - 387 WP_003407162.1 anti-sigma-F factor antagonist RsfA -
IRY56_RS07155 1538089..1538910 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
IRY56_RS07160 1538903..1539139 + 237 WP_003407167.1 hypothetical protein Antitoxin
IRY56_RS07165 1539211..1540416 - 1206 WP_003918234.1 serine hydrolase -
IRY56_RS07170 1540719..1541504 + 786 WP_003407180.1 lipoprotein LprF -
IRY56_RS07175 1541700..1543170 + 1471 Protein_1412 fatty acid desaturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T181227 WP_003407164.1 NZ_CP064405:1538089-1538910 [Mycobacterium tuberculosis variant bovis BCG]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

>T181227 NZ_CP085813:4448278-4448763 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT181227 WP_003407167.1 NZ_CP064405:1538903-1539139 [Mycobacterium tuberculosis variant bovis BCG]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp

>AT181227 NZ_CP085813:4448003-4448290 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References