181218

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 757024..757712 Replicon chromosome
Accession NZ_CP064405
Organism Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag IRY56_RS03470 Protein ID WP_003403386.1
Coordinates 757024..757461 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag IRY56_RS03475 Protein ID WP_003911263.1
Coordinates 757458..757712 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRY56_RS03440 753275..754285 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
IRY56_RS03445 754673..755056 - 384 WP_003403365.1 ribonuclease VapC6 -
IRY56_RS03450 755151..755306 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
IRY56_RS03455 755382..756098 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
IRY56_RS03460 756374..756682 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
IRY56_RS03465 756669..756914 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
IRY56_RS03470 757024..757461 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
IRY56_RS03475 757458..757712 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
IRY56_RS03480 757826..760189 + 2364 WP_003403397.1 arylsulfatase AtsD -
IRY56_RS03485 760252..760578 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
IRY56_RS03490 760490..760828 + 339 WP_003403405.1 PIN domain-containing protein -
IRY56_RS03495 760825..760998 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T181218 WP_003403386.1 NZ_CP064405:c757461-757024 [Mycobacterium tuberculosis variant bovis BCG]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T181218 NZ_CP085813:c2011911-2011756 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT181218 WP_003911263.1 NZ_CP064405:c757712-757458 [Mycobacterium tuberculosis variant bovis BCG]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp

>AT181218 NZ_CP085813:2011923-2011981 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References