Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 754673..755306 Replicon chromosome
Accession NZ_CP064405
Organism Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag IRY56_RS03445 Protein ID WP_003403365.1
Coordinates 754673..755056 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag IRY56_RS03450 Protein ID WP_003403368.1
Coordinates 755151..755306 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRY56_RS03420 749965..750501 + 537 WP_003403341.1 50S ribosomal protein L10 -
IRY56_RS03425 750538..750930 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
IRY56_RS03430 750923..751618 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
IRY56_RS03435 751689..753194 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
IRY56_RS03440 753275..754285 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
IRY56_RS03445 754673..755056 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
IRY56_RS03450 755151..755306 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IRY56_RS03455 755382..756098 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
IRY56_RS03460 756374..756682 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
IRY56_RS03465 756669..756914 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
IRY56_RS03470 757024..757461 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
IRY56_RS03475 757458..757712 - 255 WP_003911263.1 antitoxin VapB7 -
IRY56_RS03480 757826..760189 + 2364 WP_003403397.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T181215 WP_003403365.1 NZ_CP064405:c755056-754673 [Mycobacterium tuberculosis variant bovis BCG]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T181215 NZ_CP085813:359411-359824 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT181215 WP_003403368.1 NZ_CP064405:c755306-755151 [Mycobacterium tuberculosis variant bovis BCG]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT181215 NZ_CP085813:359164-359430 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References