Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 717576..718225 Replicon chromosome
Accession NZ_CP064405
Organism Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag IRY56_RS03260 Protein ID WP_003403236.1
Coordinates 717830..718225 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag IRY56_RS03255 Protein ID WP_003403235.1
Coordinates 717576..717830 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRY56_RS03230 712701..712784 + 84 Protein_640 galactose-1-phosphate uridylyltransferase -
IRY56_RS03235 712803..713885 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
IRY56_RS03240 713882..714973 + 1092 WP_003403225.1 galactokinase -
IRY56_RS03245 715368..716525 + 1158 WP_003903091.1 hypothetical protein -
IRY56_RS03250 716536..717483 + 948 WP_003403232.1 DUF732 domain-containing protein -
IRY56_RS03255 717576..717830 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
IRY56_RS03260 717830..718225 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
IRY56_RS03265 718319..719059 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
IRY56_RS03270 719191..719451 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
IRY56_RS03275 719448..719855 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
IRY56_RS03280 719927..721078 - 1152 WP_003403248.1 FIST C-terminal domain-containing protein -
IRY56_RS03285 721171..722898 - 1728 WP_010950423.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T181213 WP_003403236.1 NZ_CP064405:717830-718225 [Mycobacterium tuberculosis variant bovis BCG]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T181213 NZ_CP085812:c3985215-3984931 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACAACACAGAAGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT181213 WP_003403235.1 NZ_CP064405:717576-717830 [Mycobacterium tuberculosis variant bovis BCG]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT181213 NZ_CP085812:c3985453-3985205 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References