Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 711947..712572 Replicon chromosome
Accession NZ_CP064405
Organism Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag IRY56_RS03225 Protein ID WP_003403218.1
Coordinates 712171..712572 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag IRY56_RS03220 Protein ID WP_003403213.1
Coordinates 711947..712174 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRY56_RS03195 707126..707347 - 222 WP_003898525.1 DUF4926 domain-containing protein -
IRY56_RS03200 707489..708094 + 606 WP_003898526.1 hypothetical protein -
IRY56_RS03205 708113..710680 - 2568 WP_003900188.1 SEC-C domain-containing protein -
IRY56_RS03210 710764..711513 + 750 WP_003898528.1 hypothetical protein -
IRY56_RS03215 711510..711752 + 243 WP_003403210.1 hypothetical protein -
IRY56_RS03220 711947..712174 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
IRY56_RS03225 712171..712572 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
IRY56_RS03230 712701..712784 + 84 Protein_640 galactose-1-phosphate uridylyltransferase -
IRY56_RS03235 712803..713885 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
IRY56_RS03240 713882..714973 + 1092 WP_003403225.1 galactokinase -
IRY56_RS03245 715368..716525 + 1158 WP_003903091.1 hypothetical protein -
IRY56_RS03250 716536..717483 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T181212 WP_003403218.1 NZ_CP064405:712171-712572 [Mycobacterium tuberculosis variant bovis BCG]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T181212 NZ_CP085812:c2925626-2925408 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACAATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT181212 WP_003403213.1 NZ_CP064405:711947-712174 [Mycobacterium tuberculosis variant bovis BCG]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT181212 NZ_CP085812:c2926028-2925654 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAAC
ATATTGCAACTTTCGCTCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References