Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 704409..705052 Replicon chromosome
Accession NZ_CP064405
Organism Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag IRY56_RS03175 Protein ID WP_003403187.1
Coordinates 704651..705052 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag IRY56_RS03170 Protein ID WP_003403184.1
Coordinates 704409..704654 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRY56_RS03135 699689..700219 - 531 WP_003917320.1 two component system sensor kinase HK2 -
IRY56_RS03140 700203..700964 - 762 WP_010950420.1 two-component system response regulator TcrA -
IRY56_RS03145 701021..701332 + 312 WP_003403164.1 hypothetical protein -
IRY56_RS03150 701404..702354 + 951 WP_003907436.1 DUF1259 domain-containing protein -
IRY56_RS03155 702595..703179 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
IRY56_RS03160 703181..703891 + 711 Protein_626 transposase -
IRY56_RS03165 703894..704364 + 471 WP_003898523.1 hypothetical protein -
IRY56_RS03170 704409..704654 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IRY56_RS03175 704651..705052 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
IRY56_RS03180 705440..705607 - 168 WP_077385191.1 DUF3800 domain-containing protein -
IRY56_RS03185 705640..705837 - 198 WP_003403191.1 hypothetical protein -
IRY56_RS03190 705917..707074 - 1158 WP_003403193.1 hypothetical protein -
IRY56_RS03195 707126..707347 - 222 WP_003898525.1 DUF4926 domain-containing protein -
IRY56_RS03200 707489..708094 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T181211 WP_003403187.1 NZ_CP064405:704651-705052 [Mycobacterium tuberculosis variant bovis BCG]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T181211 NZ_CP085812:2288187-2288495 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGGTTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT181211 WP_003403184.1 NZ_CP064405:704409-704654 [Mycobacterium tuberculosis variant bovis BCG]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT181211 NZ_CP085812:2287945-2288184 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTGCTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References