Detailed information of TA system TA181207

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 445364..446375
• Replicon: chromosome
• Accession: NZ_CP064405
• Organism: Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: L7N5R2
• Locus tag: IRY56_RS01915
• Protein ID: WP_003401859.1
• Coordinates: 445364..445957 (-)
• Length: 198 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: O53702
• Locus tag: IRY56_RS01920
• Protein ID: WP_003401860.1
• Coordinates: 445986..446375 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IRY56_RS01895	441013..442395	+	1383	WP_003898415.1	magnesium transporter	-
IRY56_RS01900	442407..443441	-	1035	WP_003401856.1	class II fructose-bisphosphate aldolase	-
IRY56_RS01905	443537..444220	+	684	WP_010950388.1	VTT domain-containing protein	-
IRY56_RS01910	444209..445339	-	1131	WP_003401858.1	hypothetical protein	-
IRY56_RS01915	445364..445957	-	594	WP_003401859.1	zeta toxin family protein	Toxin
IRY56_RS01920	445986..446375	-	390	WP_003401860.1	hypothetical protein	Antitoxin
IRY56_RS01925	446456..447667	-	1212	WP_003401861.1	VWA domain-containing protein	-
IRY56_RS01930	447673..448275	-	603	WP_003898417.1	SRPBCC family protein	-
IRY56_RS01935	448289..449185	-	897	WP_003401863.1	MoxR family ATPase	-
IRY56_RS01940	449182..449775	-	594	WP_003401864.1	NTP transferase domain-containing protein	-
IRY56_RS01945	449772..450527	-	756	WP_003401865.1	XdhC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-156)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 198 a.a.
• Molecular weight: 21344.53 Da
• Isoelectric Point: 10.5018

>T181207 WP_003401859.1 NZ_CP064405:c445957-445364 [Mycobacterium tuberculosis variant bovis BCG]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Nucleotide

• Length: 594 bp

>T181207 NZ_CP085812:c1767499-1767188 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13648.21 Da
• Isoelectric Point: 6.0829

>AT181207 WP_003401860.1 NZ_CP064405:c446375-445986 [Mycobacterium tuberculosis variant bovis BCG]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Nucleotide

• Length: 390 bp

>AT181207 NZ_CP085812:c1767191-1766745 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Structures

Toxin

• AlphaFold DB: A0A7U4BRU8

Antitoxin

• AlphaFold DB: A0A7U4BRT0