Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 331069..331778 Replicon chromosome
Accession NZ_CP064405
Organism Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia

Toxin (Protein)


Gene name vapC Uniprot ID P9WF84
Locus tag IRY56_RS01470 Protein ID WP_003401406.1
Coordinates 331069..331497 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7U4BRN8
Locus tag IRY56_RS01475 Protein ID WP_011799093.1
Coordinates 331521..331778 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRY56_RS01445 326936..328069 - 1134 WP_003401394.1 hypothetical protein -
IRY56_RS01450 328066..328686 - 621 WP_003401397.1 TetR/AcrR family transcriptional regulator -
IRY56_RS01455 328783..329364 + 582 WP_003401399.1 VOC family protein -
IRY56_RS01460 329294..330019 - 726 WP_003902925.1 TetR/AcrR family transcriptional regulator -
IRY56_RS01465 330109..331029 + 921 WP_003401404.1 DUF2236 domain-containing protein -
IRY56_RS01470 331069..331497 - 429 WP_003401406.1 type II toxin-antitoxin system VapC family toxin Toxin
IRY56_RS01475 331521..331778 - 258 WP_011799093.1 ribbon-helix-helix domain-containing protein Antitoxin
IRY56_RS01480 331863..334613 - 2751 WP_011799094.1 PE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-39)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15887.27 Da        Isoelectric Point: 7.2214

>T181203 WP_003401406.1 NZ_CP064405:c331497-331069 [Mycobacterium tuberculosis variant bovis BCG]
MFLIDVNVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLTTNRRIFEIPSPRADAFAFVEAVNAQPHHL
PTSPGPRHLVLLRKLCDEADASGDLIPDAVLGAIAVEHHCAVVSLDRDFARFASVRHIRPPI

Download         Length: 429 bp

>T181203 NZ_CP085811:c3882602-3882189 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.32 Da        Isoelectric Point: 10.6530

>AT181203 WP_011799093.1 NZ_CP064405:c331778-331521 [Mycobacterium tuberculosis variant bovis BCG]
MRTTVSISDELLATAKRRARERGQSLGAVIEDALRRELAAARTGGARPTVPVFDAGTGPRPGIDLTSNRVLSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT181203 NZ_CP085811:c3882849-3882583 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTGATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRN8

References