181194

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1407259..1407916 Replicon chromosome
Accession NZ_CP064403
Organism Pseudomonas aeruginosa strain WTJH12

Toxin (Protein)


Gene name hicA Uniprot ID A0A8G3IXE4
Locus tag ITG71_RS06610 Protein ID WP_003098540.1
Coordinates 1407734..1407916 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ITG71_RS06605 Protein ID WP_003124172.1
Coordinates 1407259..1407687 (-) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITG71_RS06565 (ITG71_06565) 1403000..1403713 + 714 WP_003159463.1 phage antirepressor KilAC domain-containing protein -
ITG71_RS32745 1403820..1403918 + 99 Protein_1300 helix-turn-helix domain-containing protein -
ITG71_RS32750 1404207..1404539 + 333 WP_193377561.1 hypothetical protein -
ITG71_RS06575 (ITG71_06575) 1404536..1405219 + 684 WP_033955044.1 replication protein P -
ITG71_RS06580 (ITG71_06580) 1405216..1405422 + 207 WP_003159465.1 hypothetical protein -
ITG71_RS06585 (ITG71_06585) 1405479..1405790 + 312 WP_261995160.1 Ref family protein -
ITG71_RS06590 (ITG71_06590) 1405787..1406134 + 348 WP_222821337.1 RusA family crossover junction endodeoxyribonuclease -
ITG71_RS06595 (ITG71_06595) 1406131..1406430 + 300 WP_033950491.1 hypothetical protein -
ITG71_RS06600 (ITG71_06600) 1406468..1407142 + 675 WP_222821338.1 hypothetical protein -
ITG71_RS06605 (ITG71_06605) 1407259..1407687 - 429 WP_003124172.1 hypothetical protein Antitoxin
ITG71_RS06610 (ITG71_06610) 1407734..1407916 - 183 WP_003098540.1 type II toxin-antitoxin system HicA family toxin Toxin
ITG71_RS06615 (ITG71_06615) 1408132..1408653 + 522 WP_134230616.1 GspH/FimT family pseudopilin -
ITG71_RS06620 (ITG71_06620) 1408836..1409168 + 333 WP_003129668.1 phage holin, lambda family -
ITG71_RS06625 (ITG71_06625) 1409165..1409782 + 618 WP_222821339.1 glycoside hydrolase family 19 protein -
ITG71_RS32755 (ITG71_06630) 1409800..1410231 + 432 WP_261995158.1 hypothetical protein -
ITG71_RS06635 (ITG71_06635) 1410368..1410772 + 405 WP_014602592.1 HNH endonuclease -
ITG71_RS06640 (ITG71_06640) 1410854..1411336 + 483 WP_033940323.1 phage terminase small subunit P27 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1388983..1430273 41290


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-78)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6746.86 Da        Isoelectric Point: 11.0775

>T181194 WP_003098540.1 NZ_CP064403:c1407916-1407734 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGAKEMPEPTRKAIIKQLGLK

Download         Length: 183 bp

>T181194 NZ_CP085810:4358131-4358439 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGGTTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15770.97 Da        Isoelectric Point: 4.6562

>AT181194 WP_003124172.1 NZ_CP064403:c1407687-1407259 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKAHAISEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KVALWNEMIRRDMRKADLCRLLGIAQIQGDRLVDFLHNTKMEAMENALSALGLRLSVNIEAA

Download         Length: 429 bp

>AT181194 NZ_CP085810:4357889-4358128 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTGCTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References