181193

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142633..143138 Replicon chromosome
Accession NZ_CP064403
Organism Pseudomonas aeruginosa strain WTJH12

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag ITG71_RS00655 Protein ID WP_003121619.1
Coordinates 142633..142914 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag ITG71_RS00660 Protein ID WP_003112628.1
Coordinates 142911..143138 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITG71_RS00630 (ITG71_00630) 137884..139233 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
ITG71_RS00635 (ITG71_00635) 139282..139968 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
ITG71_RS00640 (ITG71_00640) 140069..140803 + 735 WP_003117208.1 GntR family transcriptional regulator -
ITG71_RS00645 (ITG71_00645) 140983..141393 + 411 WP_003101225.1 aegerolysin family protein -
ITG71_RS00650 (ITG71_00650) 141425..142333 - 909 WP_016561475.1 LysR family transcriptional regulator -
ITG71_RS00655 (ITG71_00655) 142633..142914 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
ITG71_RS00660 (ITG71_00660) 142911..143138 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
ITG71_RS00665 (ITG71_00665) 143314..143934 - 621 WP_034063665.1 hypothetical protein -
ITG71_RS00670 (ITG71_00670) 144035..144535 + 501 WP_023107528.1 LEA type 2 family protein -
ITG71_RS00675 (ITG71_00675) 144608..144949 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
ITG71_RS00680 (ITG71_00680) 145031..146458 - 1428 WP_003083784.1 GABA permease -
ITG71_RS00685 (ITG71_00685) 146627..148120 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T181193 WP_003121619.1 NZ_CP064403:c142914-142633 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T181193 NZ_CP085810:4317525-4317809 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT181193 WP_003112628.1 NZ_CP064403:c143138-142911 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT181193 NZ_CP085810:4317293-4317535 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAGGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAGGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References