Detailed information of TA system TA181188

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4650124..4651382
• Replicon: chromosome
• Accession: NZ_CP064401
• Organism: Pseudomonas aeruginosa strain NDTH10366

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: ITG67_RS21715
• Protein ID: WP_003112528.1
• Coordinates: 4650124..4650879 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: ITG67_RS21720
• Protein ID: WP_003086329.1
• Coordinates: 4651014..4651382 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ITG67_RS21705 (ITG67_21705)	4645297..4647840	+	2544	WP_031755663.1	acyl-homoserine-lactone acylase QuiP	-
ITG67_RS21710 (ITG67_21710)	4647995..4649356	-	1362	WP_073647918.1	DNA recombination protein RmuC	-
ITG67_RS21715 (ITG67_21715)	4650124..4650879	-	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
ITG67_RS21720 (ITG67_21720)	4651014..4651382	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
ITG67_RS21725 (ITG67_21725)	4651455..4652741	-	1287	WP_003163134.1	FAD-binding oxidoreductase	-
ITG67_RS21730 (ITG67_21730)	4652797..4654386	-	1590	WP_074231416.1	aldehyde dehydrogenase family protein	-
ITG67_RS21735 (ITG67_21735)	4654465..4654941	+	477	WP_003112531.1	hypothetical protein	-
ITG67_RS21740 (ITG67_21740)	4654944..4655219	-	276	WP_169057979.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T181188 WP_003112528.1 NZ_CP064401:c4650879-4650124 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T181188 NZ_CP085810:c2827741-2827328 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT181188 WP_003086329.1 NZ_CP064401:c4651382-4651014 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT181188 NZ_CP085810:c2827988-2827722 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTGATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7