Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3970002..3971222 Replicon chromosome
Accession NZ_CP064401
Organism Pseudomonas aeruginosa strain NDTH10366

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ITG67_RS18455 Protein ID WP_003160088.1
Coordinates 3970644..3971222 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ITG67_RS18450 Protein ID WP_003088112.1
Coordinates 3970002..3970556 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITG67_RS18425 (ITG67_18430) 3965570..3966121 + 552 WP_003132721.1 XRE family transcriptional regulator -
ITG67_RS18430 (ITG67_18435) 3966118..3966516 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
ITG67_RS18435 (ITG67_18440) 3966529..3966852 - 324 WP_003102734.1 multidrug efflux SMR transporter -
ITG67_RS18440 (ITG67_18445) 3967183..3967644 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
ITG67_RS18445 (ITG67_18450) 3967649..3969844 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
ITG67_RS18450 (ITG67_18455) 3970002..3970556 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
ITG67_RS18455 (ITG67_18460) 3970644..3971222 + 579 WP_003160088.1 HD domain-containing protein Toxin
ITG67_RS18460 (ITG67_18465) 3971331..3972518 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
ITG67_RS18465 (ITG67_18470) 3972508..3974679 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
ITG67_RS18470 (ITG67_18475) 3974669..3975946 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T181187 WP_003160088.1 NZ_CP064401:3970644-3971222 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T181187 NZ_CP085810:c1663526-1663423 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT181187 WP_003088112.1 NZ_CP064401:3970002-3970556 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT181187 NZ_CP085810:1663421-1663564 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References