Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 178729..179234 Replicon chromosome
Accession NZ_CP064401
Organism Pseudomonas aeruginosa strain NDTH10366

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag ITG67_RS00830 Protein ID WP_003121619.1
Coordinates 178729..179010 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag ITG67_RS00835 Protein ID WP_003112628.1
Coordinates 179007..179234 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITG67_RS00805 (ITG67_00805) 173980..175329 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
ITG67_RS00810 (ITG67_00810) 175378..176064 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
ITG67_RS00815 (ITG67_00815) 176165..176899 + 735 WP_003117208.1 GntR family transcriptional regulator -
ITG67_RS00820 (ITG67_00820) 177079..177489 + 411 WP_003101225.1 aegerolysin family protein -
ITG67_RS00825 (ITG67_00825) 177521..178429 - 909 WP_016561475.1 LysR family transcriptional regulator -
ITG67_RS00830 (ITG67_00830) 178729..179010 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
ITG67_RS00835 (ITG67_00835) 179007..179234 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
ITG67_RS00840 (ITG67_00840) 179410..180030 - 621 WP_003101226.1 hypothetical protein -
ITG67_RS00845 (ITG67_00845) 180131..180631 + 501 WP_003112629.1 LEA type 2 family protein -
ITG67_RS00850 (ITG67_00850) 180704..181045 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
ITG67_RS00855 (ITG67_00855) 181127..182554 - 1428 WP_003083784.1 GABA permease -
ITG67_RS00860 (ITG67_00860) 182723..184216 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T181184 WP_003121619.1 NZ_CP064401:c179010-178729 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T181184 NZ_CP085809:c4487552-4487067 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGACGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT181184 WP_003112628.1 NZ_CP064401:c179234-179007 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT181184 NZ_CP085809:c4487827-4487540 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAGTCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References