Detailed information of TA system TA181182

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PfiT-PfiA/ParE(toxin)
• Location: 4980025..4980633
• Replicon: chromosome
• Accession: NZ_CP064399
• Organism: Pseudomonas aeruginosa strain QZPH41

Toxin (Protein)

• Gene name: PfiT
• Uniprot ID: -
• Locus tag: ITG68_RS23260
• Protein ID: WP_016263850.1
• Coordinates: 4980025..4980372 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: PfiA
• Uniprot ID: A0A0B0C355
• Locus tag: ITG68_RS23265
• Protein ID: WP_003114155.1
• Coordinates: 4980382..4980633 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ITG68_RS23240 (ITG68_23230)	4976839..4977270	+	432	WP_031632963.1	hypothetical protein	-
ITG68_RS31000	4977257..4978180	+	924	WP_261990935.1	hypothetical protein	-
ITG68_RS23250 (ITG68_23240)	4978292..4978498	+	207	WP_071534345.1	AlpA family phage regulatory protein	-
ITG68_RS23255 (ITG68_23245)	4978504..4979706	-	1203	WP_028680753.1	integrase family protein	-
ITG68_RS23260 (ITG68_23250)	4980025..4980372	-	348	WP_016263850.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ITG68_RS23265 (ITG68_23255)	4980382..4980633	-	252	WP_003114155.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ITG68_RS23270 (ITG68_23260)	4980847..4981830	-	984	WP_019725833.1	tyrosine-type recombinase/integrase	-
ITG68_RS23275 (ITG68_23265)	4981830..4983122	-	1293	WP_003115206.1	hypothetical protein	-
ITG68_RS23280 (ITG68_23270)	4983352..4984626	-	1275	WP_038820714.1	zonular occludens toxin family protein	-
ITG68_RS23285 (ITG68_23275)	4984630..4984986	-	357	WP_003114150.1	DUF2523 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	catB7	-	4928320..5002309	73989

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13046.85 Da
• Isoelectric Point: 4.4212

>T181182 WP_016263850.1 NZ_CP064399:c4980372-4980025 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLVPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Nucleotide

• Length: 348 bp

>T181182 NZ_CP085809:c3868355-3867957 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTGAAATTCATGCTTGATACCAATACTTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCACCGG
AGCGTAATTTTGCAGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTACCGAACTGGCCCGCAAGGGAACACCTGTCGGGTCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9442.79 Da
• Isoelectric Point: 9.4808

>AT181182 WP_003114155.1 NZ_CP064399:c4980633-4980382 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Nucleotide

• Length: 252 bp

>AT181182 NZ_CP085809:c3868582-3868355 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGCACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0B0C355