Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4457337..4458595 Replicon chromosome
Accession NZ_CP064399
Organism Pseudomonas aeruginosa strain QZPH41

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag ITG68_RS20650 Protein ID WP_222831226.1
Coordinates 4457337..4458092 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag ITG68_RS20655 Protein ID WP_222831227.1
Coordinates 4458227..4458595 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITG68_RS20640 (ITG68_20630) 4452510..4455053 + 2544 WP_003123188.1 acyl-homoserine-lactone acylase QuiP -
ITG68_RS20645 (ITG68_20635) 4455208..4456569 - 1362 WP_222831681.1 DNA recombination protein RmuC -
ITG68_RS20650 (ITG68_20640) 4457337..4458092 - 756 WP_222831226.1 RES family NAD+ phosphorylase Toxin
ITG68_RS20655 (ITG68_20645) 4458227..4458595 - 369 WP_222831227.1 DUF2384 domain-containing protein Antitoxin
ITG68_RS20660 (ITG68_20650) 4458668..4459954 - 1287 WP_222831228.1 FAD-binding oxidoreductase -
ITG68_RS20665 (ITG68_20655) 4460010..4461599 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
ITG68_RS20670 (ITG68_20660) 4461678..4462154 + 477 WP_004353334.1 elongation factor GreAB -
ITG68_RS20675 (ITG68_20665) 4462157..4462432 - 276 WP_222831229.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28268.40 Da        Isoelectric Point: 7.7294

>T181179 WP_222831226.1 NZ_CP064399:c4458092-4457337 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

>T181179 NZ_CP085809:1932229-1932331 [Salmonella enterica subsp. enterica serovar Typhimurium]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13395.68 Da        Isoelectric Point: 9.9874

>AT181179 WP_222831227.1 NZ_CP064399:c4458595-4458227 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYVLFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp

>AT181179 NZ_CP085809:c1932333-1932190 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References