Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3521676..3522897 Replicon chromosome
Accession NZ_CP064399
Organism Pseudomonas aeruginosa strain QZPH41

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ITG68_RS16280 Protein ID WP_003160088.1
Coordinates 3522319..3522897 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ITG68_RS16275 Protein ID WP_003088112.1
Coordinates 3521676..3522230 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITG68_RS16250 (ITG68_16245) 3517244..3517795 + 552 WP_003102727.1 XRE family transcriptional regulator -
ITG68_RS16255 (ITG68_16250) 3517792..3518190 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
ITG68_RS16260 (ITG68_16255) 3518203..3518526 - 324 WP_003102734.1 multidrug efflux SMR transporter -
ITG68_RS16265 (ITG68_16260) 3518857..3519318 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
ITG68_RS16270 (ITG68_16265) 3519323..3521518 + 2196 WP_003114948.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
ITG68_RS16275 (ITG68_16270) 3521676..3522230 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
ITG68_RS16280 (ITG68_16275) 3522319..3522897 + 579 WP_003160088.1 HD domain-containing protein Toxin
ITG68_RS16285 (ITG68_16280) 3523006..3524193 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
ITG68_RS16290 (ITG68_16285) 3524183..3526354 - 2172 WP_023116610.1 type I secretion system permease/ATPase -
ITG68_RS16295 (ITG68_16290) 3526344..3527621 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T181178 WP_003160088.1 NZ_CP064399:3522319-3522897 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T181178 NZ_CP085809:779144-779431 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGTAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT181178 WP_003088112.1 NZ_CP064399:3521676-3522230 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT181178 NZ_CP085809:779418-779720 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGACAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGACGTTATGGAATGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTGAATGCCATTCTGCGCGAAGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References