Detailed information of TA system TA181176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 144178..144683
• Replicon: chromosome
• Accession: NZ_CP064399
• Organism: Pseudomonas aeruginosa strain QZPH41

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: ITG68_RS00670
• Protein ID: WP_003083773.1
• Coordinates: 144178..144459 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: ITG68_RS00675
• Protein ID: WP_003083775.1
• Coordinates: 144456..144683 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ITG68_RS00645 (ITG68_00645)	139429..140778	+	1350	WP_222831400.1	C4-dicarboxylate transporter DctA	-
ITG68_RS00650 (ITG68_00650)	140827..141513	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
ITG68_RS00655 (ITG68_00655)	141614..142348	+	735	WP_003117208.1	GntR family transcriptional regulator	-
ITG68_RS00660 (ITG68_00660)	142528..142938	+	411	WP_003101225.1	aegerolysin family protein	-
ITG68_RS00665 (ITG68_00665)	142970..143878	-	909	WP_003083769.1	LysR family transcriptional regulator	-
ITG68_RS00670 (ITG68_00670)	144178..144459	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
ITG68_RS00675 (ITG68_00675)	144456..144683	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
ITG68_RS00680 (ITG68_00680)	144859..145479	-	621	WP_003101226.1	hypothetical protein	-
ITG68_RS00685 (ITG68_00685)	145580..146080	+	501	WP_222831401.1	LEA type 2 family protein	-
ITG68_RS00690 (ITG68_00690)	146153..146494	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
ITG68_RS00695 (ITG68_00695)	146576..148003	-	1428	WP_003083784.1	GABA permease	-
ITG68_RS00700 (ITG68_00700)	148172..149665	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T181176 WP_003083773.1 NZ_CP064399:c144459-144178 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T181176 NZ_CP085809:558268-558756 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATCTCCGCCCCTGAACCGCTTCATGCCGGGCATATTCTTACCCCCTTCTGCTGCGGTGTGGATTCAATGGATAACTG
GCTAAAACAGCGGGCGATGAAAAATCAGGTAACTGGCGCATCCCGTACCTTTGTGTGTTGCGGCAGCGATTCTGACGTAC
TGGCGTATTATTCGCTGGCGTCCAGCGCGGTAACGACAAACACCGCCCCCGGTCGCTTTCGTCGCAATATGCCCGATCCG
ATCCCGGTTGTGGTGCTGGGCCGTCTGGCGGTGGATCGGTCGCTACATGGGCAGGGCGTAGGTCGGGCGCTGGTGAGGGA
TGCCGGGCTGCGGGTGATTCAGGTGGCGGAAACTATCGGTATTCGCGGGATGCTGGTCCATGCCCTGTCGGATGAAGCGC
GGGAGTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTT
CATGCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT181176 WP_003083775.1 NZ_CP064399:c144683-144456 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT181176 NZ_CP085809:557978-558271 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCAGTCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGCATCAAGCCCGCCGAGCGCGATCTTATCGA
TCGGGCTGCAAAAGCCAGAGGGAAAAACTGCACAGACTTTGTGCTAGAAGCTGCCCGCGCCGCCGCCGAGGAAGCGCTGA
TCGAGCAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGCATTTCTGATCCGTCTGGATCAGGCTCCTGCGCCAAAC
GATGCGTTGCGTAAAACCATGCAGACTCCTGCACCGTGGGAGCAGGAAAAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9