Detailed information of TA system TA181171

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3717449..3718669
• Replicon: chromosome
• Accession: NZ_CP064397
• Organism: Pseudomonas aeruginosa strain SRRSH1002

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: ITG69_RS16960
• Protein ID: WP_003160088.1
• Coordinates: 3718091..3718669 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: ITG69_RS16955
• Protein ID: WP_003088112.1
• Coordinates: 3717449..3718003 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ITG69_RS16930 (ITG69_16935)	3713017..3713568	+	552	WP_003132721.1	XRE family transcriptional regulator	-
ITG69_RS16935 (ITG69_16940)	3713565..3713963	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
ITG69_RS16940 (ITG69_16945)	3713976..3714299	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
ITG69_RS16945 (ITG69_16950)	3714630..3715091	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
ITG69_RS16950 (ITG69_16955)	3715096..3717291	+	2196	WP_003122807.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
ITG69_RS16955 (ITG69_16960)	3717449..3718003	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
ITG69_RS16960 (ITG69_16965)	3718091..3718669	+	579	WP_003160088.1	HD domain-containing protein	Toxin
ITG69_RS16965 (ITG69_16970)	3718778..3719965	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
ITG69_RS16970 (ITG69_16975)	3719955..3722126	-	2172	WP_009876279.1	type I secretion system permease/ATPase	-
ITG69_RS16975 (ITG69_16980)	3722116..3723393	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21816.65 Da
• Isoelectric Point: 5.1625

>T181171 WP_003160088.1 NZ_CP064397:3718091-3718669 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Nucleotide

• Length: 579 bp

>T181171 NZ_CP085808:4197142-4197453 [Salmonella enterica subsp. enterica serovar Typhi]
GTGCATGTTATCAGCCGAAAACTGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCGCTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT181171 WP_003088112.1 NZ_CP064397:3717449-3718003 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT181171 NZ_CP085808:4197450-4197896 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG