181165

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4795077..4795717 Replicon chromosome
Accession NZ_CP064395
Organism Pseudomonas aeruginosa strain SRRSH1408

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ITG72_RS22240 Protein ID WP_003134109.1
Coordinates 4795077..4795487 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ITG72_RS22245 Protein ID WP_031634724.1
Coordinates 4795487..4795717 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITG72_RS22195 (ITG72_22195) 4790113..4791438 + 1326 WP_191519258.1 STY4528 family pathogenicity island replication protein -
ITG72_RS32430 4791435..4791947 + 513 WP_223697281.1 hypothetical protein -
ITG72_RS22210 (ITG72_22210) 4792104..4792832 + 729 WP_009315862.1 TIGR03761 family integrating conjugative element protein -
ITG72_RS22215 (ITG72_22215) 4792838..4793368 + 531 WP_121372660.1 DUF3158 family protein -
ITG72_RS22220 (ITG72_22220) 4793382..4793870 + 489 WP_023104904.1 single-stranded DNA-binding protein -
ITG72_RS22225 (ITG72_22225) 4794369..4794566 + 198 WP_191519259.1 CrpP family ICE-associated protein -
ITG72_RS22230 (ITG72_22230) 4794632..4794850 - 219 WP_023083218.1 hypothetical protein -
ITG72_RS22235 (ITG72_22235) 4794900..4795061 - 162 WP_191519260.1 hypothetical protein -
ITG72_RS22240 (ITG72_22240) 4795077..4795487 - 411 WP_003134109.1 tRNA(fMet)-specific endonuclease VapC Toxin
ITG72_RS22245 (ITG72_22245) 4795487..4795717 - 231 WP_031634724.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
ITG72_RS22250 (ITG72_22250) 4796035..4797960 + 1926 WP_191519261.1 type I DNA topoisomerase -
ITG72_RS22255 (ITG72_22255) 4797968..4798720 + 753 WP_191519262.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - katA 4776614..4903462 126848


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-33)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15452.78 Da        Isoelectric Point: 7.3233

>T181165 WP_003134109.1 NZ_CP064395:c4795487-4795077 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVTPIV

Download         Length: 411 bp

>T181165 NZ_CP085808:c2309260-2309158 [Salmonella enterica subsp. enterica serovar Typhi]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8420.29 Da        Isoelectric Point: 4.2821

>AT181165 WP_031634724.1 NZ_CP064395:c4795717-4795487 [Pseudomonas aeruginosa]
VEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 231 bp

>AT181165 NZ_CP085808:2309156-2309299 [Salmonella enterica subsp. enterica serovar Typhi]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References