Detailed information of TA system TA181164

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4719332..4720590
• Replicon: chromosome
• Accession: NZ_CP064395
• Organism: Pseudomonas aeruginosa strain SRRSH1408

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: ITG72_RS21830
• Protein ID: WP_003112528.1
• Coordinates: 4719332..4720087 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: ITG72_RS21835
• Protein ID: WP_003086329.1
• Coordinates: 4720222..4720590 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ITG72_RS21820 (ITG72_21820)	4714505..4717048	+	2544	WP_031755663.1	acyl-homoserine-lactone acylase QuiP	-
ITG72_RS21825 (ITG72_21825)	4717203..4718564	-	1362	WP_073647918.1	DNA recombination protein RmuC	-
ITG72_RS21830 (ITG72_21830)	4719332..4720087	-	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
ITG72_RS21835 (ITG72_21835)	4720222..4720590	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
ITG72_RS21840 (ITG72_21840)	4720663..4721949	-	1287	WP_003163134.1	FAD-binding oxidoreductase	-
ITG72_RS21845 (ITG72_21845)	4722005..4723594	-	1590	WP_074231416.1	aldehyde dehydrogenase family protein	-
ITG72_RS21850 (ITG72_21850)	4723673..4724149	+	477	WP_003112531.1	hypothetical protein	-
ITG72_RS21855 (ITG72_21855)	4724152..4724427	-	276	WP_169057979.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T181164 WP_003112528.1 NZ_CP064395:c4720087-4719332 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T181164 NZ_CP085808:c941144-940926 [Salmonella enterica subsp. enterica serovar Typhi]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT181164 WP_003086329.1 NZ_CP064395:c4720590-4720222 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT181164 NZ_CP085808:c941546-941172 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7