Detailed information of TA system TA181163

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3715900..3717120
• Replicon: chromosome
• Accession: NZ_CP064395
• Organism: Pseudomonas aeruginosa strain SRRSH1408

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: ITG72_RS16945
• Protein ID: WP_003160088.1
• Coordinates: 3716542..3717120 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: ITG72_RS16940
• Protein ID: WP_003088112.1
• Coordinates: 3715900..3716454 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ITG72_RS16915 (ITG72_16920)	3711468..3712019	+	552	WP_003132721.1	XRE family transcriptional regulator	-
ITG72_RS16920 (ITG72_16925)	3712016..3712414	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
ITG72_RS16925 (ITG72_16930)	3712427..3712750	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
ITG72_RS16930 (ITG72_16935)	3713081..3713542	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
ITG72_RS16935 (ITG72_16940)	3713547..3715742	+	2196	WP_003122807.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
ITG72_RS16940 (ITG72_16945)	3715900..3716454	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
ITG72_RS16945 (ITG72_16950)	3716542..3717120	+	579	WP_003160088.1	HD domain-containing protein	Toxin
ITG72_RS16950 (ITG72_16955)	3717229..3718416	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
ITG72_RS16955 (ITG72_16960)	3718406..3720577	-	2172	WP_009876279.1	type I secretion system permease/ATPase	-
ITG72_RS16960 (ITG72_16965)	3720567..3721844	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21816.65 Da
• Isoelectric Point: 5.1625

>T181163 WP_003160088.1 NZ_CP064395:3716542-3717120 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Nucleotide

• Length: 579 bp

>T181163 NZ_CP085808:c526786-526259 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACAAAAACCTACGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT181163 WP_003088112.1 NZ_CP064395:3715900-3716454 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT181163 NZ_CP085808:c527073-526783 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGATTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA