Detailed information of TA system TA181160

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 176102..176607
• Replicon: chromosome
• Accession: NZ_CP064395
• Organism: Pseudomonas aeruginosa strain SRRSH1408

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A069QL22
• Locus tag: ITG72_RS00815
• Protein ID: WP_003121619.1
• Coordinates: 176102..176383 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q9I707
• Locus tag: ITG72_RS00820
• Protein ID: WP_003112628.1
• Coordinates: 176380..176607 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ITG72_RS00790 (ITG72_00790)	171353..172702	+	1350	WP_003119513.1	C4-dicarboxylate transporter DctA	-
ITG72_RS00795 (ITG72_00795)	172751..173437	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
ITG72_RS00800 (ITG72_00800)	173538..174272	+	735	WP_003117208.1	GntR family transcriptional regulator	-
ITG72_RS00805 (ITG72_00805)	174452..174862	+	411	WP_003101225.1	aegerolysin family protein	-
ITG72_RS00810 (ITG72_00810)	174894..175802	-	909	WP_016561475.1	LysR family transcriptional regulator	-
ITG72_RS00815 (ITG72_00815)	176102..176383	-	282	WP_003121619.1	type II toxin-antitoxin system toxin ParE	Toxin
ITG72_RS00820 (ITG72_00820)	176380..176607	-	228	WP_003112628.1	CopG family ribbon-helix-helix protein	Antitoxin
ITG72_RS00825 (ITG72_00825)	176783..177403	-	621	WP_003101226.1	hypothetical protein	-
ITG72_RS00830 (ITG72_00830)	177504..178004	+	501	WP_003112629.1	LEA type 2 family protein	-
ITG72_RS00835 (ITG72_00835)	178077..178418	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
ITG72_RS00840 (ITG72_00840)	178500..179927	-	1428	WP_003083784.1	GABA permease	-
ITG72_RS00845 (ITG72_00845)	180096..181589	-	1494	WP_003083788.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10492.22 Da
• Isoelectric Point: 10.0435

>T181160 WP_003121619.1 NZ_CP064395:c176383-176102 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T181160 NZ_CP085807:4752877-4753188 [Salmonella enterica subsp. enterica serovar Typhi]
GTGCATGTTATCAGCCGAAAACTGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCGCTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8568.64 Da
• Isoelectric Point: 5.5740

>AT181160 WP_003112628.1 NZ_CP064395:c176607-176380 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT181160 NZ_CP085807:4753185-4753631 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Structures

Toxin

• AlphaFold DB: A0A069QL22

Antitoxin

• AlphaFold DB: Q9I707