Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3715912..3717132 Replicon chromosome
Accession NZ_CP064393
Organism Pseudomonas aeruginosa strain SRRSH1101

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ITG66_RS16945 Protein ID WP_003160088.1
Coordinates 3716554..3717132 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ITG66_RS16940 Protein ID WP_003088112.1
Coordinates 3715912..3716466 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITG66_RS16915 (ITG66_16920) 3711480..3712031 + 552 WP_003132721.1 XRE family transcriptional regulator -
ITG66_RS16920 (ITG66_16925) 3712028..3712426 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
ITG66_RS16925 (ITG66_16930) 3712439..3712762 - 324 WP_003102734.1 multidrug efflux SMR transporter -
ITG66_RS16930 (ITG66_16935) 3713093..3713554 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
ITG66_RS16935 (ITG66_16940) 3713559..3715754 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
ITG66_RS16940 (ITG66_16945) 3715912..3716466 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
ITG66_RS16945 (ITG66_16950) 3716554..3717132 + 579 WP_003160088.1 HD domain-containing protein Toxin
ITG66_RS16950 (ITG66_16955) 3717241..3718428 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
ITG66_RS16955 (ITG66_16960) 3718418..3720589 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
ITG66_RS16960 (ITG66_16965) 3720579..3721856 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T181155 WP_003160088.1 NZ_CP064393:3716554-3717132 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T181155 NZ_CP085807:c4018060-4017773 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGTAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT181155 WP_003088112.1 NZ_CP064393:3715912-3716466 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT181155 NZ_CP085807:c4017786-4017484 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGACAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGACGTTATGGAATGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTGAATGCCATTCTGCGCGAAGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References